HEMOFEEL CH is a hemofilter for continuous renal support made of polymethylmethacrylate (PMMA) membrane with excellent biocompatibility and also unique characteristics of absorbing proteins. In vitro experiments have shown that the PMMA hemofilter has an inflammatory cytokine adsorptive capability.


HEMOFEEL CH is designed for the continuous replacement of the main activity of the kidneys by removing water and toxins at a slow and steady rate.

Production sales agency:

Toray Industries, Inc.

Model number, specifications

Type CH-1.8W
Fibers Polymethylmethacrylate (PMMA)
Inside diameter (μm) 240
Membrane thickness (μm) 30
Effective surface area (m2) 1.8
Sterilization Gamma-ray Irradiation
Blood volume *1 (mL) 130
Sieving coefficient *2
 Albumin 0.004
 Inulin 1.0
UFR in vitro *3 (mL/hr/mmHg) 30
Max. TMP (kPa (mmHg)) 66 (500)
Range of blood flow rates (mL/min) 100-300
  1. *1 Blood volumes are typical data.
  2. *2 Sieving coefficients are typical measured data with bovine plasma. TP: 5.5-6.5 g/dL, QB: 200 ± 4 mL/min, QF: 30.0 ± 3.0 mL/min/m2, Temp: 37 ± 1℃
  3. *3 UFRs are typical measured data with bovine blood. Ht: 32 ± 2%, TP: 5.5-6.5 g/dL, QB: 200 ± 4 mL/min, Temp: 37±1℃, TMP: 13.3 ± 1.3 kPa (100 ± 10 mmHg)



Treatment of severe sepsis and septic shock by CHDF using a PMMA membrane hemofilter as a cytokine modulator
Nakamura M et al. Contrib Nephrol. 2010;166:73-82.

Randomized controlled trial:

Continuous renal replacement therapy with a polymethyl methacrylate membrane hemofilter suppresses inflammation in patients after open-heart surgery with cardiopulmonary bypass
Mukaida H et al. J Artif Organs. 2018;21:188-195.

Observational study:

Continuous hemodiafiltration with PMMA Hemofilter in the treatment of patients with septic shock
Nakada TA et al. Mol Med. 2008;14:257-263.

Case reports:

Group A Streptococcal Toxic Shock-Like Syndrome in a Male Presenting as Primary Peritonitis: A Case Report and a Review in Japan
Sakuraba S et al. Case Rep Gastrointest Med. 2019:4984679.

Case reports:

The role of hypercytokinemia in the pathophysiology of tumor lysis syndrome (TLS) and the treatment with continuous hemodiafiltration using a polymethylmethacrylate membrane hemofilter (PMMA-CHDF)
Nakamura M et al. Transfus Apher Sci. 2009;40:41-47.

in vitro experiments:

Comparison of interleukin-6 removal properties among hemofilters consisting of varying membrane materials and surface areas: an in vitro study
Hirayama Y et al. Blood Purif. 2011;31:18-25.